' 
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: About 1/4 cup (31 g)
Amount Per Serving
%DV
Calories
180
Total Fat
13 g
17%
Saturated Fat
3 g
15%
Trans Fat
0 g
Cholesterol
0 mg
0%
Sodium
0 mg
0%
Total Carbohydrate
4 g
1%
Dietary Fiber
2 g
7%
Total Sugars
0 g
Includes 0g Added Sugars
0%
Protein
11g
Vit. D
0 mcg
0%
Calcium
8 mg
0%
Iron
4 mg
20%
Potassium
243 mg
6%
Top Medical Research Studies
9
CNP may ease knee osteoarthritis
C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee.
Study directly addresses knee pain
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Read More
7
Collagen supplementation benefits knee pain
The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.
Study explores collagen's effectiveness
We conducted a randomized, double-blind, placebo-controlled study to examine whether collagen supplementation could alleviate knee pain in patients suffering from meniscopathy. Our group consisted of 32 patients, with some receiving a supplement made from types I, II, and III collagen, while others received a placebo.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Read More
7
Collagen supplementation aids knee pain
Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study.
Combines multiple collagen types
This study examined how a specific collagen supplement, Naturagen® 4 Joint, impacts knee pain and overall living quality for those suffering from osteoarthritis (OA). It involved 31 participants, split into two groups: one received the collagen supplement, while the other received a placebo, ensuring a fair comparison.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Read More
Most Useful Reviews
8.3
Cystitis relief
Pumpkin seeds are beneficial for eye health and have helped me with my knee pain, particularly cystitis, which I suffered from for years. Since I started consuming them consistently, I've been pain-free. I even recommended them to a colleague with cataracts, and he postponed surgery due to improved eyesight.
Read More
8.8
Reduced throat pain
I used it personally, and it alleviated my slight throat pain within a few days. After a week, I tried it on my 10-year-old son. He reported feeling a strong heat, but I advised him to drink water to ease it. Thankfully, by the second day, his pain significantly improved. I was initially anxious about the product's effectiveness.
Read More
8.8
Effective for pain
It’s good, with excellent ingredients that offer benefits during pain. It contains antioxidants and comes in a full, well-closed package. I find it helpful for managing discomfort and appreciate the luxurious quality.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
9
CNP may ease knee osteoarthritis
C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee.
Study directly addresses knee pain
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Read More
9
Protein therapy shows promise
Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models.
Moderate relevance observed
We examined how delivering proteins directly into the joints could impact knee pain associated with osteoarthritis (OA). The study focused on two proteins: interleukin-1 receptor antagonist (IL-1Ra), which helps reduce inflammation, and SOX9, which supports cartilage repair. Using a gene therapy approach, we injected these proteins via a viral vector into animal models that were induced with knee osteoarthritis.
Our results were promising. In one test with a rat model, we saw improvements in gait and a reduction in cartilage damage after injecting IL-1Ra alone. This suggests that IL-1Ra can significantly alleviate pain and damage in knees suffering from OA.
Additionally, when we combined IL-1Ra with SOX9, the effects were even more beneficial. This joint delivery significantly improved not only the inflammation of the synovial tissue but also protected cartilage, leading to enhanced overall joint health compared to using either protein separately.
Overall, our findings indicate that targeting knee pain with these proteins could pave the way for new therapeutic strategies in treating osteoarthritis, highlighting the potential of tailored protein treatments for better patient outcomes.
Our results were promising. In one test with a rat model, we saw improvements in gait and a reduction in cartilage damage after injecting IL-1Ra alone. This suggests that IL-1Ra can significantly alleviate pain and damage in knees suffering from OA.
Additionally, when we combined IL-1Ra with SOX9, the effects were even more beneficial. This joint delivery significantly improved not only the inflammation of the synovial tissue but also protected cartilage, leading to enhanced overall joint health compared to using either protein separately.
Overall, our findings indicate that targeting knee pain with these proteins could pave the way for new therapeutic strategies in treating osteoarthritis, highlighting the potential of tailored protein treatments for better patient outcomes.
Read More
7
Collagen supplementation benefits knee pain
The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.
Study explores collagen's effectiveness
We conducted a randomized, double-blind, placebo-controlled study to examine whether collagen supplementation could alleviate knee pain in patients suffering from meniscopathy. Our group consisted of 32 patients, with some receiving a supplement made from types I, II, and III collagen, while others received a placebo.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Read More
7
Collagen supplementation aids knee pain
Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study.
Combines multiple collagen types
This study examined how a specific collagen supplement, Naturagen® 4 Joint, impacts knee pain and overall living quality for those suffering from osteoarthritis (OA). It involved 31 participants, split into two groups: one received the collagen supplement, while the other received a placebo, ensuring a fair comparison.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
8.8
Reduced throat pain
I used it personally, and it alleviated my slight throat pain within a few days. After a week, I tried it on my 10-year-old son. He reported feeling a strong heat, but I advised him to drink water to ease it. Thankfully, by the second day, his pain significantly improved. I was initially anxious about the product's effectiveness.
Read More
8.8
Effective for pain
It’s good, with excellent ingredients that offer benefits during pain. It contains antioxidants and comes in a full, well-closed package. I find it helpful for managing discomfort and appreciate the luxurious quality.
8.3
Cystitis relief
Pumpkin seeds are beneficial for eye health and have helped me with my knee pain, particularly cystitis, which I suffered from for years. Since I started consuming them consistently, I've been pain-free. I even recommended them to a colleague with cataracts, and he postponed surgery due to improved eyesight.
Read More
1
Mixed results
The unsalted pumpkin seeds are sweet, but I experienced knee pain on my left side while consuming them, prompting me to stop. I had my sister try them, and she felt fine. Results seem to vary from person to person.
